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Pfizer’s shot left fewer than half of participants with side effects

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pfizers shot left fewer than half of participants with side effects

A second experimental coronavirus vaccine being tested by Pfizer Inc and its German partner BioNTech SE showed promising results.

The two companies say their second jab produced just as many antibodies in volunteers as their first jab did, but had far fewer side effects.

Results published on Wednesday in The New England Journal of Medicine showed that the first shot was more likely to cause pain at the injection site, fever, fatigue and chills compared to the second shot. 

It was also better tolerated by elderly participants, who are much less likely to have vaccines induce immune responses due to their weakened immune systems.

The findings comes on the heels of Pfizer announcing it plans to enroll participants as young as age 12 in its large, late-stage COVID-19 vaccine trial to understand how the immunization works in a younger age group.

The coronavirus vaccines being tested by Pfizer Inc and BioNTech SE use genetic code with B1 encoding for part of the protein the virus uses to enter and infect human cells and B2 encoding for all of the protein. Pictured: Pfizer Inc headquarters in New York City, July 22

The coronavirus vaccines being tested by Pfizer Inc and BioNTech SE use genetic code with B1 encoding for part of the protein the virus uses to enter and infect human cells and B2 encoding for all of the protein. Pictured: Pfizer Inc headquarters in New York City, July 22

The coronavirus vaccines being tested by Pfizer Inc and BioNTech SE use genetic code with B1 encoding for part of the protein the virus uses to enter and infect human cells and B2 encoding for all of the protein. Pictured: Pfizer Inc headquarters in New York City, July 22

After receiving B1, 77% of 18-to-55 year olds suffered reactions compared to 75% after B2, although there were fewer reports of redness and swelling

After receiving B1, 77% of 18-to-55 year olds suffered reactions compared to 75% after B2, although there were fewer reports of redness and swelling

After receiving B1, 77% of 18-to-55 year olds suffered reactions compared to 75% after B2, although there were fewer reports of redness and swelling

About 80% of adults aged 65 to 85 reported mild to moderate reactions after B1 compared to  55% in B2, which caused no redness or swelling after either dose

About 80% of adults aged 65 to 85 reported mild to moderate reactions after B1 compared to  55% in B2, which caused no redness or swelling after either dose

About 80% of adults aged 65 to 85 reported mild to moderate reactions after B1 compared to  55% in B2, which caused no redness or swelling after either dose 

Each vaccine candidate from Pfizer and BioNTech uses part of the pathogen’s genetic code, called mRNA, to get the body to recognize the coronavirus and attack it if a person becomes infected.

In the first vaccine, BNT162b1 (B1), the mRNA encodes for part of the protein the virus uses to enter and infect human cells.

For the second vaccine, BNT162b2 (B2) the mRNA encodes for all of the protein, called the spike protein

In the randomized, placebo-controlled trial, researchers tested a low-dose at 10 micrograms (µg), a medium dose at 20 µg and a high-dose at 30 µg.

A total of 195 participants were split into groups of 15 each in which they either  received two doses 21 days apart of the 10 µg, 20 µg or 30 µg or a placebo. 

About 77 percent of 18-to-55 year olds and 80 percent of adults aged 65 to 85 who received B1 reported mild to moderate reactions.

The most common side effect was pain at the injection site within seven days of being inoculated. 

Antibody levels in the older group were lower than in the younger group, but still higher than those seen in recovered patients (above)

Antibody levels in the older group were lower than in the younger group, but still higher than those seen in recovered patients (above)

Antibody levels in the older group were lower than in the younger group, but still higher than those seen in recovered patients (above)

It comes as Pfizer announced it was looking to enroll participants as young as age 12 in its trial. Pictured: The first patient enrolled in Pfizer's COVID-19 coronavirus vaccine clinical trial at the University of Maryland School of Medicine in Baltimore, receives an injection, May 4

It comes as Pfizer announced it was looking to enroll participants as young as age 12 in its trial. Pictured: The first patient enrolled in Pfizer's COVID-19 coronavirus vaccine clinical trial at the University of Maryland School of Medicine in Baltimore, receives an injection, May 4

It comes as Pfizer announced it was looking to enroll participants as young as age 12 in its trial. Pictured: The first patient enrolled in Pfizer’s COVID-19 coronavirus vaccine clinical trial at the University of Maryland School of Medicine in Baltimore, receives an injection, May 4

A few participants also reported redness and swelling, particularly after the 30 µg dose. 

By comparison, 75 percent of 18-to-55 year olds and 55 percent of 65-to-85 year olds reported reactions to B2.

A few in the younger group reported redness or swelling after Dose 1 of B2 but none did after dose 2. 

None of the older group had redness or swelling after either dose – just pain at the injection site.

Additionally, the authors note that the B1 vaccine was more likely to induce side effects such as fever, fatigue and chills, than B2.

‘Systemic events (fatigue, headache, chills , muscle pain and joint paint) were reported in small numbers of younger recipients of [B2], but no severe systemic events were reported by older recipients of this vaccine candidate,’ the authors wrote.

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No volunteers in any groups experienced events described as ‘grade 4,’ which are often life-threatening or require hospitalization. 

The team says that antibody levels were similar among patients who received either the B1 or B2 vaccine. 

Levels of IgG antibodies, which bind to the virus, and neutralizing antibodies were boosted by the second dose in younger participants, but less so in older participants.

However, levels were still higher than those seen in recovered patients, according to the study.

Last month, Pfizer announced it was scaling up its trial to include up to 44,000 participants, an increase from 30,000, and include those HIV, hepatitis C and hepatitis B. 

As of Monday, nearly 38,000 people have enrolled at trial sites in four countires, including the US.  

The results also come as several drugmakers paused their own late-stage coronavirus vaccine trials 

Johnson & Johnson paused its trial on Monday due to ‘unexplained illness’ in one participant, the details of which are unclear.

Meanwhile, the US arm of the trial for Oxford University and AstraZeneca’s vaccine has been on hold since last month, though testing has resumed at all other sites. 

Additionally, Eli Lilly  announced on Wednesday it would continue testinh its coronavirus antibody drugs after placing a hold on at least one trial due to ‘potential safety concerns.’

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This post first appeared on dailymail.co.uk

Australia

Radical plans to transform a ‘tired, tourist trap’ in the heart of Sydney into waterfront boulevard

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radical plans to transform a tired tourist trap in the heart of sydney into waterfront boulevard

Developers have released plans to radically revamp the Harbourside Shopping Centre in Sydney’s Darling Harbour to include a 42-storey residential tower.

Dubbed a ‘tired, tourist trap’, the harbour area is being designed by architecture firm FJMT, who have now released their plans for the $1.8billion redevelopment.

The site opened during Australia’s Bicentennial celebrations in 1988, before it was bought for $252million by Mirvac in 2013.

The renewed plans will demolish the current shopping centre, monorail structure and pedestrian bridge at Darling Drive to put in retail spaces.

Restaurants, open areas, a civic square and a wider waterfront boulevard with a footbridge to Pyrmont will also create 8,000 square metres of public space.

Developers wish to erect a 42-storey tall residential tower (plans pictured) at the Harbourside Shopping Centre in Darling Harbour

Developers wish to erect a 42-storey tall residential tower (plans pictured) at the Harbourside Shopping Centre in Darling Harbour

Developers wish to erect a 42-storey tall residential tower (plans pictured) at the Harbourside Shopping Centre in Darling Harbour

Mirvac have plans to 'immeasurably improve' the current shopping centre (pictured) at Darling Harbour

Mirvac have plans to 'immeasurably improve' the current shopping centre (pictured) at Darling Harbour

Mirvac have plans to ‘immeasurably improve’ the current shopping centre (pictured) at Darling Harbour 

The developers told Architecture AU the site is ‘outdated and in decline’. 

Initial plans for the site were criticised due to the size of the residential tower, with locals concerned it would block waterfront views and cause overshadowing.

Mirvac’s updated proposal has removed one to three storeys from the northern side of the tower and created a 1,500 metre open area called Guardian Square.

But 13m have also been added to the building to restore it to the original height of 166m.

Buildings must be a maximum of 170m tall to be allowed in the precinct. 

FJMT believe the taller and narrower building will offset some of the impact of the view. 

‘The tower adopts an elongated plan, with the narrow facade oriented to the east and west, with wider facades to the north and south,’ they said.

Developers hope to put in retail spaces, restaurants, open areas, a civic square and a wider waterfront boulevard with a footbridge to Pyrmont to create 8,000 square metres of public space (plans pictured)

Developers hope to put in retail spaces, restaurants, open areas, a civic square and a wider waterfront boulevard with a footbridge to Pyrmont to create 8,000 square metres of public space (plans pictured)

Developers hope to put in retail spaces, restaurants, open areas, a civic square and a wider waterfront boulevard with a footbridge to Pyrmont to create 8,000 square metres of public space (plans pictured)

‘The narrow waterfront tower facade coupled with the current podium form and set back will provide opportunity for a high level of amenity at ground plane with consideration of wind.’

A response to public submissions by Mirvac consultants Ethos Urban said the site would be ‘immeasurably improved’ in the development.

‘The existing Harbourside Shopping Centre presents as a dominant, bland, tired and unattractive building,’ the report reads.

‘Mirvac plan to undertake a design competition for the project which will deliver a future building of the highest standard of architectural, urban and landscape design.’

The demolition of the current site would take eight months before construction could commence, creating 6,000 jobs including 2,100 in the demolition.

Locals are concerned the 166 metre high tower will block water views and cause overshadowing. Pictured: the current Harbourside Shopping Centre site

Locals are concerned the 166 metre high tower will block water views and cause overshadowing. Pictured: the current Harbourside Shopping Centre site

Locals are concerned the 166 metre high tower will block water views and cause overshadowing. Pictured: the current Harbourside Shopping Centre site

This post first appeared on dailymail.co.uk

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Australia

Jared Kushner says Donald Trump – NOT doctors – back in charge

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jared kushner says donald trump not doctors back in charge

Donald Trump son in law Jared Kushner made up-beat comments about the coronavirus to journalist Bob Woodward back in April, telling him the president was ‘back in charge’ and was ‘getting the country back from the doctors.’

The comment appeared to put the president at odds with the nation’s top medical professionals, who nominally were on the same team as a White House coronavirus task force and other government officials sought to pull the country out of the coronavirus pandemic.

Kushner also told the Watergate journalist the country was in the ‘comeback phase’ – a prediction that proved optimistic. The country hit a record 500,000 new infections over the last week.

Donald Trump son in law Kushner called a date in April 'the beginning of the comeback phase' on coronavirus

Donald Trump son in law Kushner called a date in April 'the beginning of the comeback phase' on coronavirus

Donald Trump son in law Kushner called a date in April ‘the beginning of the comeback phase’ on coronavirus

Kushner, who like Trump came from New York real estate and who is now a senior White House advisor and top campaign official, put the pandemic in simple terms.

‘There were three phases. There’s the panic phase, the pain phase and then the comeback phase. I do believe that last night symbolized kind of the beginning of the comeback phase,’ he told Woodward April 18.

CNN broadcast audio of the recording. 

His comments came a day after Trump tweeted out an appeal to ‘LIBERATE MICHIGAN!’ as well as Minnesota and Virginia amid lockdowns. 

He made the taped comments to Bob Woodward

He made the taped comments to Bob Woodward

He made the taped comments to Bob Woodward

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Kushner said Trump was 'getting the country back from the doctors'

Kushner said Trump was 'getting the country back from the doctors'

Kushner said Trump was ‘getting the country back from the doctors’

White House senior advisor Jared Kushner and current President of the Ultimate Fighting Championship Dana White listen as U.S. President Donald Trump delivers remarks at his hotel in Las Vegas, Nevada, U.S., October 28, 2020

White House senior advisor Jared Kushner and current President of the Ultimate Fighting Championship Dana White listen as U.S. President Donald Trump delivers remarks at his hotel in Las Vegas, Nevada, U.S., October 28, 2020

White House senior advisor Jared Kushner and current President of the Ultimate Fighting Championship Dana White listen as U.S. President Donald Trump delivers remarks at his hotel in Las Vegas, Nevada, U.S., October 28, 2020

Ivanka Trump and husband Jared Kushner pose with mail-in ballots for New York on Air Force One just after her father rails against voting my mail

Ivanka Trump and husband Jared Kushner pose with mail-in ballots for New York on Air Force One just after her father rails against voting my mail

Ivanka Trump and husband Jared Kushner pose with mail-in ballots for New York on Air Force One just after her father rails against voting my mail

Kushner's comment hinted at tension between Trump and experts on the coronavirus task force

Kushner's comment hinted at tension between Trump and experts on the coronavirus task force

Kushner’s comment hinted at tension between Trump and experts on the coronavirus task force

Since the spring, the White House task force has met much less frequently, and experts Dr. Deborah Birx and Dr. Anthony Fauci have had much less facetime with the president. 

Trump has turned to controversial Dr. Scott Atlas, who is not an infectious disease expert, for much of his advice on the pandemic. The president continues to say the nation is ’rounding the corner.’

Kushner, who is married to Ivanka Trump, also said the president did a ‘full hostile takeover’ of the GOP.

Trump himself gave 18 hours of interviews to Woodward, and has been burned by on-record comments he made. 

The president told Woodward February 7 ‘this is deadly stuff’ and called it ‘more deadly than even your strenuous flus,’ even as he publicly compared the deadly virus to the flu and said it would go away.

‘I wanted to always play it down,’ Trump told Woodward in March.  

Kushner in a recording also dissed the GOP platform – there wasn’t one this year but in the past it has been the subject of intense ideological battles – as ‘a document meant to, like, piss people off, basically.’

The pandemic has continued to rage in the intervening months; Trump and first lady Melania Trump caught the virus; and a White House ceremony for now Justice Amy Coney Barrett turned into a superspreader event.

More than 8 million Americans have become infected.  

This post first appeared on dailymail.co.uk

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Coles Australia supermarket scanning error policy mean you could get FREE meat

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coles australia supermarket scanning error policy mean you could get free meat

A woman has warned shoppers to always check their receipts before leaving the supermarket after she was given free meat due to a little-known policy.

The customer, from Forbes in New South Wales, picked up a tray of porterhouse steaks at Coles, which was on sale for $28 a kilo, after being discounted from $34.

But she quickly noticed she was overcharged when she checked her docket and saw the red meat had scanned at $34/kg – $6 more than the advertised ‘special’ price.

The shopper was supposed to pay $13.32 at $28/kg instead of $16.18 at $34/kg. 

And so she was able to get the steaks without paying a cent because the item scanned at a higher price than what was ticketed on the shelf.

Under Coles’ ‘Promise on Price Scanning’ policy, if a single item scans at a higher price than the advertised or ticketed shelf price for that item, the store will give that item to the customer for free.

A woman has warned shoppers to always check their receipts before leaving the supermarket after she was given free meat due to a little-known policy

A woman has warned shoppers to always check their receipts before leaving the supermarket after she was given free meat due to a little-known policy

A woman has warned shoppers to always check their receipts before leaving the supermarket after she was given free meat due to a little-known policy

The customer, from Forbes in New South Wales, picked up a tray of porterhouse steaks at Coles, which was on sale for $28 per kilo, after being discounted from $34

The customer, from Forbes in New South Wales, picked up a tray of porterhouse steaks at Coles, which was on sale for $28 per kilo, after being discounted from $34

The customer, from Forbes in New South Wales, picked up a tray of porterhouse steaks at Coles, which was on sale for $28 per kilo, after being discounted from $34

But she quickly noticed she was overcharged when she checked her docket and saw the red meat had scanned at $34/kg - $6 more than the advertised 'special' price. The shopper was supposed to pay $13.32 at $28/kg instead of $16.18 at $34/kg

But she quickly noticed she was overcharged when she checked her docket and saw the red meat had scanned at $34/kg - $6 more than the advertised 'special' price. The shopper was supposed to pay $13.32 at $28/kg instead of $16.18 at $34/kg

But she quickly noticed she was overcharged when she checked her docket and saw the red meat had scanned at $34/kg – $6 more than the advertised ‘special’ price. The shopper was supposed to pay $13.32 at $28/kg instead of $16.18 at $34/kg

So how do you get a free grocery item? 

Single items: If a single item scans at a higher price than the advertised or ticketed shelf price for that item, Coles will give you that item FREE.

Multiple identical items: If multiple, identical items scan at higher price than the advertised or ticketed shelf price, Coles will give you the first item FREE, and the remaining items at the advertised or ticketed shelf price.

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The woman shared her experience in a Facebook group to remind fellow shoppers to always ‘check your dockets, folks’.

She also uploaded pictures of her receipt showing proof she walked away with a free packet of steaks after she was refunded her full amount.

The receipt stated the ‘refund reason’ was a ‘scanning error’.

Many shoppers quickly responded to her post, saying they always check their dockets, while others admitted they never do.

‘Same thing happened yesterday with a roast pork. Was packaged at $10/kg advertised at $8/kg with the same yellow sign but scanned at around $9/kg so it was free,’ one woman wrote.

A second said: ‘Yep always check dockets. It’s crazy how many times you get overcharged. At least one item each shop seems to get scanned wrong. Even when I’ve pulled it up as it’s been scanned I was still given for free, which surprised me.’

And another added: ‘Just yesterday I got English muffins from a bin that said $2.50 and when I got home, I see $5 [on the receipt]. So annoying.’

On Coles’ website, the supermarket states: ‘All Coles supermarkets apply “Our Promise on Price Scanning” to ensure confidence in the pricing accuracy at our registers.’

One happy woman scored a free pack of lamb loin chops after her meat scanned at $26 per kilo - $6 more than the shelf price at Coles

One happy woman scored a free pack of lamb loin chops after her meat scanned at $26 per kilo - $6 more than the shelf price at Coles

One happy woman scored a free pack of lamb loin chops after her meat scanned at $26 per kilo – $6 more than the shelf price at Coles

What is a scanning policy?

What is a scanning error? A scanning error occurs when an item has been scanned, or the correct PLU (Price Look Up) number entered, and a price higher than the advertised or ticketed price displays at the checkout or on the receipt.

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The story comes after a group of shoppers on social media revealed they had discovered a little-known supermarket policy implemented by Coles and Woolworths. 

Customers are entitled to their product for free if the item scans at a higher price than what it was ticketed at on the shelf or on the packaging.  

But shoppers need to challenge the scanned price directly with management to get their product for free under both supermarkets’ scanning policies.

One shopper showed off the free packet of lamb loin chops she received after her meat scanned at $26 per kilo – $6 more than the shelf price.

‘Free Lamb today thanks to the Scanning Code of Practice,’ one shopper said, along with a picture of her lamb chops and a receipt showing the $0.00 transaction.

‘It scanned at $11.96 which is the correct price for $26/kg. It should have scanned at $9.20 which is $20/kg,’ the shopper explained.

Another shopper had a similar experience after her lamb roast scanned at a different price at checkout.

The label on the lamb leg roast showed it was sold at $13.50 per kilo – but the ‘Special’ label was displayed at $11 per kilo. 

One shopper claimed she purchased a Christmas ham after Woolworths had a $20 off sale – but the item scanned at just $10 off at checkout – so she got the $31 ham home for free. 

One shopper got a free beef rib steak after she noticed the 'Special' label was marked higher than the retail price

One shopper got a free beef rib steak after she noticed the 'Special' label was marked higher than the retail price

One shopper got a free beef rib steak after she noticed the ‘Special’ label was marked higher than the retail price

The label on this lamb leg roast showed it was sold at $13.50 per kilo - but the 'Special' label was displayed at $11 per kilo

The label on this lamb leg roast showed it was sold at $13.50 per kilo - but the 'Special' label was displayed at $11 per kilo

The label on this lamb leg roast showed it was sold at $13.50 per kilo – but the ‘Special’ label was displayed at $11 per kilo

Coles' policy under 'Our Promise on Price Scanning' to 'ensure confidence in the pricing accuracy at our registers'

Coles' policy under 'Our Promise on Price Scanning' to 'ensure confidence in the pricing accuracy at our registers'

Coles’ policy under ‘Our Promise on Price Scanning’ to ‘ensure confidence in the pricing accuracy at our registers’

Under Woolworths' Scanning Code of Practice, customers are entitled to receive an item free of charge if the scanned price of an item is greater than the shelf price displayed

Under Woolworths' Scanning Code of Practice, customers are entitled to receive an item free of charge if the scanned price of an item is greater than the shelf price displayed

Under Woolworths’ Scanning Code of Practice, customers are entitled to receive an item free of charge if the scanned price of an item is greater than the shelf price displayed

Woolworths has a similar policy under the ‘scanning code of practice’.

A Woolworths spokesperson told Daily Mail Australia early last year: ‘Woolworths is a signatory to the Scanning Code of Practice.

‘Under the Code, our customers are entitled to receive an item free of charge if the scanned price of an item is greater than the shelf price displayed.

‘The only exceptions under the Code are products with a shelf price greater than $50, as well as tobacco and liquor products. These products will be adjusted to reflect the shelf price.’

This post first appeared on dailymail.co.uk

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