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Daily jab could become the first treatment to slow the advance of dementia, trial suggests

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daily jab could become the first treatment to slow the advance of dementia trial suggests

A common diabetes drug could slash the risk of developing dementia, a major trial suggests.

Experts believe that, in time, it could be given to anyone at risk of developing the illness.

An international study of 15,800 people with diabetes, led by Exeter University, suggests a daily jab called liraglutide may cut the chance of developing dementia by half. Semaglutide, a similar drug taken as a pill, had the same effect.

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31522486 0 image a 43 1596487612402

An international study of 15,800 people with diabetes suggests a daily jab called liraglutide may cut the chance of developing dementia by half (file photo)

The two treatments are already widely prescribed on the NHS to type 2 diabetics manage their condition. They can also sometimes be used to tackle obesity.

But these recent findings suggest they may help ward off dementia – for which those with diabetes are at a 70 per cent increased risk.

Experts believe this could lead to wider use of the drugs by diabetics to cut their risk of developing dementia. But, crucially, they are thought to work the same for those without diabetes.

Researchers at Imperial College London are already testing liraglutide on 200 people with mild Alzheimer’s, to see if it slows the progression of the disease.

Study leader Professor Clive Ballard said: ‘These results are pretty convincing… The next question is whether these could be used for treatment of mild cognitive impairment and Alzheimer’s.’

The two drugs are in a class of GLP-1 agonists, which reduce blood sugar levels by boosting insulin production in the pancreas.

Researchers believe these drugs work on dementia by lowering blood sugar – which at high levels clogs fine blood vessels in the brain. But there is emerging evidence the treatments also reduce levels of amyloid and tau – toxic proteins that cause Alzheimer’s. Professor Ballard presented his results to the Alzheimer’s Association International Conference.

Of 7,907 people given liraglutide and semaglutide, 15 developed dementia after an average 3.6 years of monitoring. Of the 7,913 given a placebo, 32 developed dementia, suggesting the treatments cut the risk by more than half.

Researchers at Imperial College London are already testing liraglutide on 200 people with mild Alzheimer¿s, to see if it slows the progression of the disease (file photo)

Researchers at Imperial College London are already testing liraglutide on 200 people with mild Alzheimer¿s, to see if it slows the progression of the disease (file photo)

Researchers at Imperial College London are already testing liraglutide on 200 people with mild Alzheimer’s, to see if it slows the progression of the disease (file photo)

The trial was designed to assess the cardiovascular effects of the drugs, rather than the impact on dementia, so more targeted trials are needed.

But these are already under way and the Imperial study is expected to report back within months.

Fiona Carragher, of the Alzheimer’s Society, said ‘repurposing’ treatments could be a ‘game changer’. She added: ‘An estimated 850,000 people in the UK have dementia, and right now there are no drugs that can slow progression of the disease.’

Professor Ballard said if the upcoming results are as positive as expected, it would offer an effective treatment to ward off dementia for the first time.

The professor added: ‘If [the compounds] are shown to lower dementia risk in people without diabetes, we might expect them to be given to people with a vascular risk profile.’

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Britons sink a few drinks while making the most of 70F sun with warm weather to last until Tuesday

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britons sink a few drinks while making the most of 70f sun with warm weather to last until tuesday

Britons have flocked out to enjoy the last of the summer sunshine this weekend as rain is set to sweep across the nation next week.

Temperatures reached a pleasant 77F (25C) in some parts of the UK today, with people heading out across the UK to enjoy the last weekend of summer weather before rain is set to hit the nation next week. 

The warm and sunny weather comes on the first weekend since the Government introduced its new ‘rule of six’ rule amid the coronavirus pandemic.

But people still flocked outdoors to make the most of the last rays of sunshine before temperatures become cooler next week, with Tuesday and Wednesday bringing rain in from the north west of the UK. 

The Met Office had forecast a weekend of ‘largely dry, bright and fine’ weather, which has seen temperatures rise as high as 77F (25C) across the first day of the weekend.

The Met Office had forecast a weekend of 'largely dry, bright and fine' weather, which could see temperatures rise as high as 24C (75F). Pictured, picknickers enjoy the warm sunshine on the first weekend the 'rule of six' is in force

The Met Office had forecast a weekend of 'largely dry, bright and fine' weather, which could see temperatures rise as high as 24C (75F). Pictured, picknickers enjoy the warm sunshine on the first weekend the 'rule of six' is in force

The Met Office had forecast a weekend of ‘largely dry, bright and fine’ weather, which could see temperatures rise as high as 24C (75F). Pictured, picknickers enjoy the warm sunshine on the first weekend the ‘rule of six’ is in force

Metropolitan Police urged Londoners (above, drinkers at a pub in southwest London) to 'continue to act responsibly' amid forecasts of warm weather for the capital over the weekend

Metropolitan Police urged Londoners (above, drinkers at a pub in southwest London) to 'continue to act responsibly' amid forecasts of warm weather for the capital over the weekend

Metropolitan Police urged Londoners (above, drinkers at a pub in southwest London) to ‘continue to act responsibly’ amid forecasts of warm weather for the capital over the weekend

Ollie Claydon, a spokesperson for the Met Office, said that the warm weekend temperatures would come ahead of a more 'unsettled' week of weather. Above, people enjoy the warm weather in central London on September 19

Ollie Claydon, a spokesperson for the Met Office, said that the warm weekend temperatures would come ahead of a more 'unsettled' week of weather. Above, people enjoy the warm weather in central London on September 19

 Ollie Claydon, a spokesperson for the Met Office, said that the warm weekend temperatures would come ahead of a more ‘unsettled’ week of weather. Above, people enjoy the warm weather in central London on September 19

Britons sat outside to enjoy drinks in southwest London today as temperatures reached highs of 77F (25C) at Heathrow and are set to continue further into the weekend

Britons sat outside to enjoy drinks in southwest London today as temperatures reached highs of 77F (25C) at Heathrow and are set to continue further into the weekend

Britons sat outside to enjoy drinks in southwest London today as temperatures reached highs of 77F (25C) at Heathrow and are set to continue further into the weekend

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33376872 8750865 image a 23 1600535787900

Highs of 77F (25C) were recorded at Heathrow across today, as temperatures are set to hit similar highs tomorrow.

Kew Gardens and St James Park in London both reached 77F, with Kin Loch Ewe in Scotland also hitting 75F (24C). 

Ollie Claydon, a spokesperson for the Met Office, said that the warm weekend temperatures would come ahead of a more ‘unsettled’ week of weather.

‘We’re in for a dry and fine evening on Saturday, with clear conditions for central parts of the UK and northern Ireland,’ he said.

‘There’s a risk of showers but temperatures will stay high.

‘But then a cold front from the north west around lunchtime on Monday will herald the arrival of cooler, more unsettled weather next week.’

The September warmth follows on from an August heatwave which saw temperatures hit 93F (34C) for six days running last month. 

Groups of kitesurfers and windsurfers made the most of the the sunny, yet blustery weather, in Portland, Weymouth, today

Groups of kitesurfers and windsurfers made the most of the the sunny, yet blustery weather, in Portland, Weymouth, today

Groups of kitesurfers and windsurfers made the most of the the sunny, yet blustery weather, in Portland, Weymouth, today

Temperatures reached a warm 77F (25C) today, with people heading out across the UK (above, people at Boscombe beach in Dorset) to enjoy the last weekend of summer weather before rain is set to hit the nation next week

Temperatures reached a warm 77F (25C) today, with people heading out across the UK (above, people at Boscombe beach in Dorset) to enjoy the last weekend of summer weather before rain is set to hit the nation next week

Temperatures reached a warm 77F (25C) today, with people heading out across the UK (above, people at Boscombe beach in Dorset) to enjoy the last weekend of summer weather before rain is set to hit the nation next week

People in southwest London made the most of the warm weather as concerns of a second coronavirus wave rise after the new 'rule of six' came into force earlier this week

People in southwest London made the most of the warm weather as concerns of a second coronavirus wave rise after the new 'rule of six' came into force earlier this week

People in southwest London made the most of the warm weather as concerns of a second coronavirus wave rise after the new ‘rule of six’ came into force earlier this week

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure, which applies to indoor and outdoor settings

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure, which applies to indoor and outdoor settings

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure, which applies to indoor and outdoor settings

The highest temperature ever recorded in September was 96.08F (35.6C) on September 2, 1906, but they ‘don’t look like they’re going to come anywhere close to that in this current hot spell’, the forecaster said.

The warmest September day of recent years was September 13, 2016, when 93.9F (34.4C) was recorded at Gravesend, Kent – the warmest day of that year.

It comes as police forces across the UK urged people to comply with the Government’s new ‘rule of six’ during the warm and sunny weather this weekend.

Further lockdown measures were also introduced in northern parts of England, with 10pm curfews being introduced in some areas across the northeast. 

Police officers in Manchester urged people to comply with coronavirus restrictions after they were called to reports of a wedding party at a home. 

Greater Manchester Police said officers attended a property in Wythenshawe on Friday evening, having received intelligence that a wedding party was being held.

‘Police attended and found that a gazebo had been erected in the garden of a property,’ the force tweeted.

‘Officers prevented the illegal gathering before restrictions were breached.’

Police forces across the country have urged people to comply with the 'rule of six' across the sunny weekend as fears of another national lockdown increase

Police forces across the country have urged people to comply with the 'rule of six' across the sunny weekend as fears of another national lockdown increase

Police forces across the country have urged people to comply with the ‘rule of six’ across the sunny weekend as fears of another national lockdown increase

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure. Above, small groups sit outside pubs and cafes in southwest London

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure. Above, small groups sit outside pubs and cafes in southwest London

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure. Above, small groups sit outside pubs and cafes in southwest London

Highs of 77F (25C) were recorded at Heathrow across today, as temperatures are set to hit similar highs tomorrow. Pictured, groups enjoy the warm sunshine at Hyde Park in London

Highs of 77F (25C) were recorded at Heathrow across today, as temperatures are set to hit similar highs tomorrow. Pictured, groups enjoy the warm sunshine at Hyde Park in London

Highs of 77F (25C) were recorded at Heathrow across today, as temperatures are set to hit similar highs tomorrow. Pictured, groups enjoy the warm sunshine at Hyde Park in London

Meanwhile, Assistant Chief Constable Claire Nix, of Kent Police, said there would be an increased presence in ‘key areas’ around the county, as Covid-19 remains a ‘real and deadly threat’.  

The Metropolitan Police urged Londoners to ‘continue to act responsibly’ amid forecasts of warm weather for the capital over the weekend.

The force said it will continue to patrol public spaces and respond to incidents where groups of more than six are gathering, reminding the public of fines for breaching coronavirus guidelines.

Any social gathering of more than six people in England is against the law, with people facing fines of up to £3,200 if they do not abide by the new measure, which applies to both indoor and outdoor settings.

And forces in Dorset, where large crowds have previously flocked to the beaches to enjoy the heat, also warned that anyone flouting the new ‘rule of six’ over the weekend may be subject to fines. 

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Alexei Navalny back up and walking after treatment for nerve agent poisoning at Berlin hospital

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alexei navalny back up and walking after treatment for nerve agent poisoning at berlin hospital

Russian politician Alexei Navalny is back up and walking just days after being taken off a ventilator.

Navalny, the political opponent of Russian president Vladimir Putin, shared a photo of himself walking down stairs at Berlin‘s Charité Hospital, where he is continuing his recovery from being poisoned in late August.

He has said he intends to return to Russia as western governments demand an explanation from the Kremlin. 

Russian opposition leader Alexei Navalny is 'continuing to improve,' doctors say. He shared a photo and an update about his recovery from novichok nerve agent poisoning, writing that doctors at Berlin's Charité Hospital had transformed him from "technically alive" to someone with a chance at a real recovery. He said he still has issues pouring water and using his phone, but is up and walking after being taken off a ventilator earlier in the week.

Russian opposition leader Alexei Navalny is 'continuing to improve,' doctors say. He shared a photo and an update about his recovery from novichok nerve agent poisoning, writing that doctors at Berlin's Charité Hospital had transformed him from "technically alive" to someone with a chance at a real recovery. He said he still has issues pouring water and using his phone, but is up and walking after being taken off a ventilator earlier in the week.

Russian opposition leader Alexei Navalny is ‘continuing to improve,’ doctors say. He shared a photo and an update about his recovery from novichok nerve agent poisoning, writing that doctors at Berlin’s Charité Hospital had transformed him from “technically alive” to someone with a chance at a real recovery. He said he still has issues pouring water and using his phone, but is up and walking after being taken off a ventilator earlier in the week.

Laboratory tests confirmed Navalny, who was airlifted to Germany after falling ill in Siberia, was poisoned with a novichok nerve agent that is tightly controlled by the Russian government.

Navalny shared an update of his recovery on Instagram, posting a photo of him walking downstairs in the hospital wearing a navy blue t-shirt, sweatpants, and blue rubber gloves. 

He said: ‘This is a clear road, albeit a long one.’

Navalny wrote that he has trouble pouring himself some water and using his phone, describing it as ‘useless as a stone’.

Russian president Vladimir Putin (right) called accusations about possible Kremlin involvement in Navalny's poisoning 'unsubstantiated' in a call with French president Emmanuel Macron (left). Navalny is Putin's political rival and a vocal critic of the long-standing leader (file photo).

Russian president Vladimir Putin (right) called accusations about possible Kremlin involvement in Navalny's poisoning 'unsubstantiated' in a call with French president Emmanuel Macron (left). Navalny is Putin's political rival and a vocal critic of the long-standing leader (file photo).

Russian president Vladimir Putin (right) called accusations about possible Kremlin involvement in Navalny’s poisoning ‘unsubstantiated’ in a call with French president Emmanuel Macron (left). Navalny is Putin’s political rival and a vocal critic of the long-standing leader (file photo).

He said ‘there are so many problems still to be solved’ but that doctors had transformed him from ‘technically alive’ to someone who had a chance of living a normal life again.

Charité Hospital said on Monday that Navalny’s condition ‘continues to improve’.

‘The patient has been successfully removed from mechanical ventilation. He is currently undergoing mobilization and is able to leave his bed for short periods of time.’  

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Axeman jailed for four years after inflicting ‘worst example of grievous bodily harm’ judge had seen

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axeman jailed for four years after inflicting worst example of grievous bodily harm judge had seen

An axeman has been jailed for four years after inflicting the ‘worst example of grievous bodily harm’ a veteran judge had ever seen following a row with his drinking partner.  

Leon Green had been at a pub in Chard, Somerset, with victim Joseph Guppy before going back to the other man’s home.

It was then that the 34-year-old lost his temper and launched the vicious axe attack which left the victim with multiple wounds and a small fracture of the skull.

Green denied causing grievous bodily harm but was found guilty at Taunton Crown Court in July.

He has since been jailed for four years and ten months with a one-year extended licence, by Judge Linford, who was sitting at Exeter Crown Court. 

The sentence was the maximum allowed. 

Leon Green (pictured) has been jailed for four years after inflicting the 'worst example of grievous bodily harm' a veteran judge had ever seen following a row with his drinking partner

Leon Green (pictured) has been jailed for four years after inflicting the 'worst example of grievous bodily harm' a veteran judge had ever seen following a row with his drinking partner

Leon Green (pictured) has been jailed for four years after inflicting the ‘worst example of grievous bodily harm’ a veteran judge had ever seen following a row with his drinking partner

Judge Robert Linford declared that Green is a danger to the public and said the attack on Mr Guppy could easily have killed the victim.

He said some of the photographs of the wounds had even been too intense to shown the jury at the original trial at Taunton Crown Court.

Green has a long record of violence and dishonesty, including a burglary at the Yeovil Labour Club last year where he caused thousands of pounds of damage trying to break into the bar. 

He carried out the axe attack when he was part way through a ‘thinking skills course’ which he was sent on for stabbing a man with a screwdriver. 

The judge told Green: ‘You went back to Mr Guppy’s house where he was clowning around and dancing around and at some point his hand went close to your face. It was not an aggressive mood.

‘It set off the most extreme reaction. You picked up an axe and struck him repeatedly about the head and body and caused multiple wounds and a small fracture of the skull.

‘It is astonishing the injuries were not more serious than they were. You could have killed him. This is the worst example of grievous bodily harm I have ever encountered.

‘The probation report came to the conclusion that because of your record of violence and the facts of this case, you are a dangerous offender. I am in no doubt whatsoever about it.’

Green denied causing grievous bodily harm but was found guilty at Taunton Crown Court (pictured) in July

Green denied causing grievous bodily harm but was found guilty at Taunton Crown Court (pictured) in July

Green denied causing grievous bodily harm but was found guilty at Taunton Crown Court (pictured) in July

Miss Virginia Cornwall, prosecuting, said the attack on Mr Guppy happened at his home in High Street, Chard, on the night of October 10 last year after he and Green had been drinking in a nearby pub.

The burglary at the Labour Club in Yeovil took place on July 27, 2019 and police were called by a neighbour who heard banging noises from inside in the middle of the night.    

Green and another man were arrested and the club had to be closed temporarily to repair doors and shutters which had been smashed.

Mr Patrick Mason, defending, said all Green’s offending arose from a disrupted childhood in which he stopped going to school when he was 13 or 14 and fell into the company of criminals.

He said the axe attack had been excessive self defence and the raid on the Labour Club happened at a time when Green was homeless and desperate.

Green, of Perrythorne Park, Yeovil, denied causing grievous bodily harm but was found guilty at Taunton Crown Court in July. He also admitted burglary.

He was jailed for four years and ten months with a one year extended licence, by Judge Linford, who was sitting at Exeter Crown Court. The sentence was the maximum allowed. 

Police praised the courage of the victim and welcomed the sentence.

PC Jim Card said: ‘This was an extremely unpleasant incident in which Leon Green used an axe to assault another man at a property in High Street, Chard. 

‘His actions were dangerous and could have easily resulted in far more serious consequences.

‘I’d like to thank the victim and the witness for supporting our investigation and I welcome the custodial sentence given to Green in court today.’

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