Guardiola’s side are looking to move a step closer to the knockout stages of the competition, as they host the Belgian side who they beat 5-1 in the reverse fixture last month.
They then face rivals United in the lunchtime kick-off on Saturday in the first Manchester derby of the season.
Man City face Club Brugge on Wednesday before the Manchester derby on Saturday
Guardiola considers Brugge to be a ‘much more important’ game than the one against United
Ahead of their Champions League clash on Wednesday, Guardiola said in a press conference: ‘I think this game is much more important than the United game.
‘This gives us an incredible chance to qualify for the last 16 of the Champions League.
‘In the Premier League there are many games, in the Champions League just six, and there are not many left.’
City could move a step closer to qualification with a victory against the Belgian side
City go into the game second in their group, one point behind leaders Paris Saint-Germain and two ahead of the Belgian side.
A victory over Club Brugge would see them move five points clear of the third-placed side, with just six points left to fight for.
City cruised to victory on October 19 when the sides last played, with goals from Joao Cancelo, a Riyad Mahrez brace, Kyle Walker and Cole Palmer helping to seal a 5-1 victory.
When asked whether he expects a backlash on Wednesday, Guardiola said: ‘Of course. I’m pretty sure they will adjust things to punish us.
Guardiola will be hoping his side can bounce back from their defeat to Crystal Palace
City romped to a 5-1 victory when they travelled to Belgium to face Club Brugge last month
‘We have to adjust to get better. It’s normal, it will be a completely different game.’
City then face United at the weekend on the back of their 2-0 defeat the Etihad to Crystal Palace on Saturday.
Guardiola’s side sit four points behind Chelsea and will be keen to avoid dropping any more points to Thomas Tuchel’s side.
The game could be vitally important for Ole Gunnar Solskjaer, who remains under pressure following United’s 5-0 defeat to Liverpool, with a loss to City likely to raise more questions about his future at Old Trafford.